Expertise & Research | VIVANT Science

The "Hallmarks of Aging"

Why do our pets age? Science has identified 9 main causes. We focus primarily on these three:

Mitochondrial Dysfunction

Mitochondria are the power plants of cells. They lose efficiency with age. The result: The dog becomes lethargic, metabolism slows down. We aim to restore this energy production (ATP).

Cellular Senescence

So-called "zombie cells" no longer divide but do not die either. They secrete inflammatory messengers that damage surrounding tissue. Senolytics help the body dispose of this "waste".

Epigenetic Drift

Imagine DNA as a piano. Epigenetics is the pianist. With age, the pianist hits the wrong notes (genes are incorrectly switched on or off). We provide the nutrients to get the melody right again.

MOLECULAR INTERVENTION

NAD+ Restoration via NMN

Nicotinamide Mononucleotide (NMN) is the direct precursor of NAD+, a coenzyme essential for life. Without NAD+, a cell dies within seconds.

In dogs and cats, NAD+ levels drop drastically with age (up to 50%). This leads to DNA damage and lack of energy. Supplementation replenishes these stores.

"Restoring NAD+ levels in old mice rejuvenated tissues so much that they were indistinguishable from those of young mice." – Sinclair et al.

SENOLYTICS

Fisetin: Cellular Clean-up

Fisetin is a flavonoid that occurs naturally in strawberries but acts as a powerful senolytic in concentrated form. It selectively induces apoptosis (cell death) in harmful senescent cells.

Studies suggest that regularly "cleansing" the body of these cells can significantly extend healthspan by reducing systemic inflammation ("inflammaging").

Scientific Basis

Our protocols are based on peer-reviewed studies. Here is a selection of relevant literature:

NAD+ metabolism and its roles in cellular processes during aging Imai, S., & Guarente, L. (2014). Nature Reviews Molecular Cell Biology.
Fisetin is a senotherapeutic that extends health and lifespan Yousefzadeh, M. J., et al. (2018). EBioMedicine.
The Dog Aging Project: Translational Geroscience Kaeberlein, M., et al. (2018). GeroScience.

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